JAK/HDAC-IN-4
Product Specifications
UNSPSC Description
JAK/HDAC-IN-4 (compound 11 i) is a JAK/HDAC inhibitor with the IC50 values of 0.49 nM and 12 nM for JAK2 and HDAC6, respectively. JAK/HDAC-IN-4 inhibits the cell proliferation and the production of nitric oxide. JAK/HDAC-IN-4 ameliorates psoriasis-like skin lesions in an Imiquimod (HY-B0180)-induced murine model with low toxicity[1].
Target Antigen
HDAC; JAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak-hdac-in-4.html
Smiles
O=S(NC1=CC=C(C=C1)C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CC(NC5=CC=C(C=C5)C(NO)=O)=O)=NC=C2)(C)=O
Molecular Weight
616.69
References & Citations
[1]Hu W, et al. Discovery of Janus Kinase and Histone Deacetylase Dual Inhibitors as a New Strategy to Treat Psoriasis. J Med Chem. 2024 Nov 14;67(21):19267-19281.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169290/JAK-HDAC-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169290/
Clinical Information
No Development Reported
Curated Selection
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