Rotundifuran

Rotundifuran, a labdane type diterpene, is isolated from Vitex rotundifolia. Rotundifuran can inhibit the cell cycle progression and induce apoptosis in human myeloid leukaemia cells[1][2].

Product Specifications

CAS Number

[50656-65-0]

Product Name Alternative

AG-013736

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rotundifuran.html

Purity

98.35

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@]1(CCC2=COC=C2)[C@H](C)C[C@@H](OC(C)=O)[C@@]3([H])C(C)(C)CCC[C@]13C

Molecular Formula

C22H34O4

Molecular Weight

362.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Ko WG, et, al. Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells. Phytother Res. 2001 Sep; 15 (6) :535-7.|[2]Li WX, et, al. Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L. J Asian Nat Prod Res. 2005 Apr; 7 (2) : 95-105.