BET-IN-27
BET-IN-27 (compound 6C) is an oral BET inhibitor with the IC50 values of 3.3 nM (BRD4-BD2) 、3.4 nM (BRD4-BD1) 、4.1 nM (BRD2-BD1) 、20.4 nM (BRD3-BD1) and 42.0 nM (BRDT-BD1), respectively. BET-IN-27 shows anti-proliferative activity[1].
Product Specifications
CAS Number
3054869-29-0
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-27.html
Smiles
CN(C(C1=C2C=CN1)=O)C=C2C3=NC4=C(SC(C(C)(C)O)=C4)C(N5CCOCC5)=N3
Molecular Formula
C21H23N5O3S
Molecular Weight
425.50
References & Citations
[1]Ran K, Li Y, Zhang YM, et al. Discovery and optimization of novel 4-morpholinothieno[3,2-d]pyrimidine derivatives as potent BET inhibitors for cancer therapy. Bioorg Chem.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680806-500 1x 500 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881073-100 1x 100 µL
HLA-Aw32 & HLA-A25 (MHC I) (CATA-1), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880806-500 1x 500 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC741207-100 1x 100 µL
CD74 (LN-2 + CLIP/813), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details