AMG-076 (free base)
AMG-076 free base is an orally bioavailable and selective MCHR1 antagonist. AMG-076 free base results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].
Product Specifications
CAS Number
693823-79-9
UNSPSC
12352005
Target
MCHR1 (GPR24)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/amg-076-free-base.html
Smiles
O=C(C1(CCN2CC[C@]3([H])CC(NC4=C5C=C(C(F)(F)F)C=C4)=C5[C@H](C)[C@@]3([H])C2)CCCCC1)O
Molecular Formula
C26H33F3N2O2
Molecular Weight
462.55
References & Citations
[1]Alykhan S Motani, et al. Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models. Pharmacol Res Perspect. 2013 Oct;1 (1) :e00003.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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