AK59
AK59 is a STING degrader that works by leveraging HERC4, a hect domain E3 ligase. AK59 can be used in the study of autoimmune diseases and cancer[1].
Product Specifications
UNSPSC
12352005
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ak59.html
Purity
99.79
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=S(NC1=C2N=CC=CC2=C(C=C1)C3=CC=CN=C3)(C4=CC=C(C=C4)C(F)(F)F)=O
Molecular Formula
C21H14F3N3O2S
Molecular Weight
429.41
References & Citations
[1]Mutlu M, et al. Small molecule induced STING degradation facilitated by the HECT ligase HERC4. Nat Commun. 2024 May 29;15 (1) :4584.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
KLM6437 1x 96 Well
GENLISA™ Mouse TNF Receptor Associated Factor 1 (TRAF1) ELISA
Sign In for Pricing
View Details