AK59
AK59 is a STING degrader that works by leveraging HERC4, a hect domain E3 ligase. AK59 can be used in the study of autoimmune diseases and cancer[1].
Product Specifications
UNSPSC
12352005
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ak59.html
Purity
99.79
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=S(NC1=C2N=CC=CC2=C(C=C1)C3=CC=CN=C3)(C4=CC=C(C=C4)C(F)(F)F)=O
Molecular Formula
C21H14F3N3O2S
Molecular Weight
429.41
References & Citations
[1]Mutlu M, et al. Small molecule induced STING degradation facilitated by the HECT ligase HERC4. Nat Commun. 2024 May 29;15 (1) :4584.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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