Mcl-1 inhibitor 6
Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a Kd of 0.23 nM and a Ki of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, Kd>10 μM) . Mcl-1 inhibitor 6 is a potent antitumor agent[1].
Product Specifications
CAS Number
[2598978-56-2]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl-1-inhibitor-6.html
Purity
98.77
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(C)C(S(=O)(C2=CC=C(C(C)=O)C=C2)=O)=C(C)N1CCCOC3=CC(C)=C(Cl)C(C)=C3)O
Molecular Formula
C26H28ClNO6S
Molecular Weight
518.02
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-W; Bcl-xL; Bfl-1; Mcl-1
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Porimin (Keratinocytes-associated Transmembrane Protein 3, KCT-3, Pro-oncosis Receptor Inducing Membrane Injury, Transmembrane Protein 123, TMEM123, KCT3, PSEC0111, UNQ641/PRO1271) (MaxLight 490)
Porimin (Keratinocytes-associated Transmembrane Protein 3, KCT-3, Pro-oncosis Receptor Inducing Membrane Injury, Transmembrane Protein 123, TMEM123, KCT3, PSEC0111, UNQ641/PRO1271) (MaxLight 490)
Serine/threonine-protein Phosphatase 2A 65 kDa regulatory subunit A β isoform (PPP2R1B) Rat ELISA Kit
Lentiviral mouse Rab8a shRNA (UAS) - Lentiviral mouse Rab8a shRNA (UAS, RFP) plasmid