Antcin A
Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1].
Product Specifications
CAS Number
163597-24-8
UNSPSC
12352211
Target
NOD-like Receptor (NLR) ; Pyroptosis
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/antcin-a.html
Purity
99.71
Solubility
10 mM in DMSO
Smiles
C[C@@]12C3=C(CC[C@@]1([H])[C@@H](C(CC2)=O)C)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
Molecular Formula
C29H42O4
Molecular Weight
454.64
References & Citations
[1]Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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