D-erythro-Sphingosine (hydrochloride)

D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation[1][2].

Product Specifications

CAS Number

[2673-72-5]

Product Name Alternative

Erythrosphingosine (hydrochloride) ; erythro-C18-Sphingosine (hydrochloride) ; trans-4-Sphingenine (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-erythro-sphingosine-hydrochloride.html

Purity

99.87

Solubility

Ethanol : 50 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO.[H]Cl

Molecular Formula

C18H38ClNO2

Molecular Weight

335.95

Precautions

H302, H315, H319, H335

References & Citations

[1]Grimm C, et al. Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. Mol Pharmacol. 2005 Mar;67 (3) :798-805.|[2]Chao R, et al. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25;267 (33) :23459-62.