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AK-IN-1

AK-IN-1 (compound 4072-2732) is an adenosine kinase (AK) inhibitor that is competitive for adenosine (Ado) but not for ATP. AK-IN-1 inhibits 86%, 87% and 89% of AK activity at concentrations of 2, 4 and 10 µM, respectively. AK-IN-1 has good potential for research in many disease areas, including ischaemia, inflammation and seizures[1].

Product Specifications

CAS Number

378775-98-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Adenosine Kinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ak-in-1.html

Purity

99.21

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCNC1=NC=NC2=C1C(C3=CC=C(OC)C=C3)=C(C4=CC=C(C=C4)OC)O2

Molecular Formula

C22H21N3O4

Molecular Weight

391.42

Precautions

H302, H315, H319

References & Citations

[1]Park J, et al. Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase. Protein J. 2007 Apr;26 (3) :203-12.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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