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Dynamin IN-2

Dynamin IN-2 (compound 43), a Wiskostatin analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM[1].

Product Specifications

CAS Number

1345853-49-7

UNSPSC

12352005

Target

Dynamin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dynamin-in-2.html

Purity

98.93

Solubility

10 mM in DMSO

Smiles

ClC(C=C1)=CC=C1CNCC(CN2C3=CC=CC=C3C4=CC=CC=C42)O

Molecular Formula

C22H21ClN2O

Molecular Weight

364.87

References & Citations

[1]Cossar PJ, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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