MicroRNA-21-IN-1
MicroRNA-21-IN-1 (compound A7) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2) . microRNA-21-IN-1 can be used for researching anticancer[1].
Product Specifications
CAS Number
[2848720-31-8]
UNSPSC
12352005
Target
Apoptosis; MicroRNA
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microrna-21-in-1.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CCN1C=C(C(C2=CC(F)=C(C=C21)N3CCNCC3)=O)C(NC4=CC=C(C=C4)C(NCCN5CCCCC5)=O)=O
Molecular Formula
C30H37FN6O3
Molecular Weight
548.65
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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