ENMD-1198

ENMD-1198 (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-1198 is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization.

Product Specifications

CAS Number

[864668-87-1]

Product Name Alternative

IRC-110160

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase; Microtubule/Tubulin; STAT

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ENMD-119.html

Purity

98.87

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12C=CC[C@@]1([H])[C@]3([H])CCC4=C(C=C(OC)C(C(N)=O)=C4)[C@@]3([H])CC2

Molecular Formula

C20H25NO2

Molecular Weight

311.42

References & Citations

[1]Pasquier E, et al. ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Mol Cancer Ther. 2010 May;9 (5) :1408-18.|[2]Snoeks TJ, et al. 2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo. Mol Cancer Ther. 2011 May;10 (5) :874-82.|[3]Moser C, et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer. 2008 Jul 23;8:206.