RUSKI-201 (dihydrochloride)
RUSKI-201 dihydrochloride is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 0.20 μM. RUSKI-201 dihydrochloride is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 dihydrochloride is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function[1].
Product Specifications
CAS Number
2320262-09-5
UNSPSC
12352005
Target
Hedgehog
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ruski-201-dihydrochloride.html
Purity
98.20
Solubility
10 mM in DMSO
Smiles
CCC(CNCC(N1CCC2=C(C1C3=NC(C)=CC=C3)C=CS2)=O)C.Cl.Cl
Molecular Formula
C20H29Cl2N3OS
Molecular Weight
430.43
References & Citations
[1]Ursula R Rodgers, et al. Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. ACS Chem Biol. 2016 Dec 16;11 (12) :3256-3262.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AP26034PU-L 200 µg
VEGF Receptor 2 (KDR) (esKDR) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 
BNC740282-500 1x 500 µL
HER-2 / CD340 (HRB2/282), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
