Gepirone
Gepirone is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research[1].
Product Specifications
CAS Number
83928-76-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gepirone.html
Purity
99.88
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 33.33 mg/mL (ultrasonic)
Smiles
O=C(CC(C)(C)C1)N(CCCCN2CCN(C3=NC=CC=N3)CC2)C1=O
Molecular Formula
C19H29N5O2
Molecular Weight
359.47
Precautions
H302, H315, H319, H335
References & Citations
[1] Mendelson SD, et al. Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone. Eur J Pharmacol. 1986 Dec 16;132 (2-3) :323-6.|[2]Blier P, et al. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse. 1987;1 (5) :470-80.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; mLAG-3
Available Sizes
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