Gepirone

Gepirone is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research[1].

Product Specifications

CAS Number

[83928-76-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/gepirone.html

Purity

99.88

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 33.33 mg/mL (ultrasonic)

Smiles

O=C(CC(C)(C)C1)N(CCCCN2CCN(C3=NC=CC=N3)CC2)C1=O

Molecular Formula

C19H29N5O2

Molecular Weight

359.47

Precautions

H302, H315, H319, H335

References & Citations

[1] Mendelson SD, et al. Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone. Eur J Pharmacol. 1986 Dec 16;132 (2-3) :323-6.|[2]Blier P, et al. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse. 1987;1 (5) :470-80.