Ombrabulin (hydrochloride)
Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
Product Specifications
CAS Number
[253426-24-3]
Product Name Alternative
AVE8062 (hydrochloride) ; AC7700 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H341, H351, H360, H362, H372
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Ombrabulin-hydrochloride.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC)[C@@H](N)CO.[H]Cl
Molecular Formula
C21H27ClN2O6
Molecular Weight
438.90
Precautions
H341, H351, H360, H362, H372
References & Citations
[1]Kim TJ, et al. Antitumor and antivascular effects of AVE8062 in ovarian carcinoma. Cancer Res. 2007 Oct 1;67 (19) :9337-45.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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