Ravidasvir (hydrochloride)

Ravidasvir hydrochloride (PPI-668 hydrochloride) is a pan-genotypic inhibitor for hepatitis C virus (HCV) NS5A protein. Ravidasvir hydrochloride inhibits the replication of HCV, with EC50 of 0.12, 0.01 and 1.14 nM, for HCV gt-1a, gt-1b, and gt-3a replicons, respectively. Ravidasvir hydrochloride exhibits good pharmacokinetic characters in rats[1].

Product Specifications

CAS Number

[1303533-81-4]

Product Name Alternative

PPI-668 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ravidasvir-hydrochloride.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

COC(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C2=NC3=CC=C(C4=CC5=C(C=C(C6=CN=C([C@H]7N(CCC7)C([C@H](C(C)C)NC(OC)=O)=O)N6)C=C5)C=C4)C=C3N2)=O)=O.Cl.Cl

Molecular Formula

C42H52Cl2N8O6

Molecular Weight

835.82

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhong M, et al., Discovery of ravidasvir (PPI-668) as a potent pan-genotypic HCV NS5A inhibitor. Bioorg Med Chem Lett. 2016 Sep 15;26 (18) :4508-4512.