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Herbacetin (Standard)

Herbacetin (Standard) is the analytical standard of Herbacetin. This product is intended for research and analytical applications. Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2].

Product Specifications

CAS Number

527-95-7

UNSPSC

12352005

Target

Others; Reference Standards

Type

Reference Standards

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/herbacetin-standard.html

Smiles

O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=C(O)C(O)=CC(O)=C13

Molecular Formula

C15H10O7

Molecular Weight

302.24

References & Citations

[1]Veeramani C, et al. Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes. Chem Biol Interact. 2018 May 25;288:49-56.|[2]Kim DJ, et al. Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. Cancer Res. 2016 Mar 1;76 (5) :1146-1157.|[3]Qian J, Li Y, Zhang X, et al. Herbacetin Broadly Blocks the Activities of CYP450s by Different Inhibitory Mechanisms [published online ahead of print, 2021 Jun 11]. Planta Med. 2021;10.1055/a-1502-7131. |[4]Li L, Fan P, Chou H, Li J, Wang K, Li H. Herbacetin suppressed MMP9 mediated angiogenesis of malignant melanoma through blocking EGFR-ERK/AKT signaling pathway. Biochimie. 2019;162:198-207.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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