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MG degrader 1

MG degrader 1 (Compd E14) is a PROTAC degrader of IKZF3, GSPT1, and GSPT2 with an EC50 value of 1.385 nM in MM.1S cells[1].

Product Specifications

UNSPSC

12352005

Target

IKZF Family; PROTACs

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mg-degrader-1.html

Purity

99.83

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C2CCC(NC2=O)=O)C(C3=C(NCCCCNC(C(C4=CC=CC(OC)=C4)N(CC(C)C)C=O)=O)C=CC=C31)=O

Molecular Formula

C31H37N5O7

Molecular Weight

591.65

References & Citations

[1]Zefeng Wang, et al. Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery. Nat Commun. 2023 Dec 19;14 (1) :8437.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IKZF3

Available Sizes

Frequently Asked Questions

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