BACE1-IN-14
BACE1-IN-14 (compound 27f) is a BACE1 inhibitor, with the EC50 values of 0.7 μM and 1.6 μM for BACE1 and BACE2. BACE1-IN-14 is can be used in Alzheimer's disease (AD) research[1].
Product Specifications
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-in-14.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(NC(NC2=C(COC3=CC=C(C4=CC=CC=C4)C=C3)C=CC=C2)=N5)=C5C=C1
Molecular Formula
C26H20FN3O
Molecular Weight
409.45
References & Citations
[1]Quang De T, et al. Rational design of novel diaryl ether-linked benzimidazole derivatives as potent and selective BACE1 inhibitors. Biochem Biophys Res Commun. 2024 Feb 26;698:149538.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1; BACE2
Curated Selection
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