14-3-3η Protein inhibitor 1
Product Specifications
UNSPSC Description
14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a KD of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/14-3-3η-protein-inhibitor-1.html
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
COC1=CC=CC(CNCC2=C(N(C3=C2C=CC(C(C)C)=C3)CC4=CC=C(C=C4)C)C(O)=O)=C1
Molecular Weight
456.58
References & Citations
[1]Gao Z, et al. Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein. Eur J Med Chem. 2022 Apr 29;238:114402.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146302/14-3-3η-Protein-inhibitor-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146302/14-3-3η-Protein-inhibitor-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2770842-10-7
Available Sizes
Curated Selection
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