4-Aminobenzamidine (dihydrochloride)

4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor. 4-Aminobenzamidine dihydrochloride acts as an orally active urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM) . 4-Aminobenzamidine dihydrochloride can be used for cardiovascular diseases and anti-tumor study[1][2][3][4].

Product Specifications

CAS Number

[2498-50-2]

Product Name Alternative

P-Aminobenzamidine (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PAI-1; Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/4-aminobenzamidine-dihydrochloride.html

Purity

99.97

Solubility

DMSO : 23.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N=C(N)C1=CC=C(N)C=C1.[H]Cl.[H]Cl

Molecular Formula

C7H11Cl2N3

Molecular Weight

208.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Nguyen AL, et al. The development and application of a new affinity partitioning system for enzyme isolation and purification. Enzyme Microb Technol. 1990 Sep;12 (9) :663-8.|[2]Billström A, et al. The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice. Int J Cancer. 1995 May 16;61 (4) :542-7.|[3]Okumura N, et al. Cell surface-bound plasminogen regulates hepatocyte proliferation through a uPA-dependent mechanism. Biosci Biotechnol Biochem. 2007 Jun;71 (6) :1542-9.|[4]Dutra JBR, et al. p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats. Life Sci. 2022 Sep 1;304:120693.