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Phenylephrine (hydrochloride)

(R) - (-) -Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Product Specifications

CAS Number

[61-76-7]

Product Name Alternative

(R) - (-) -Phenylephrine (hydrochloride) ; L-Phenylephrine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H317, H401

Target

Adrenergic Receptor; Endogenous Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/_r_-_-_-phenylephrine-hydrochloride.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC1=CC([C@@H](O)CNC)=CC=C1.Cl

Molecular Formula

C9H14ClNO2

Molecular Weight

203.67

Precautions

H302, H317, H401

References & Citations

[1]Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121 (6) :1127-35.|[2]Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46 (5) :929-36.|[3]Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed) . 2016 Jan 1;21:502-13.|[4]Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 (Pt 2) :459-65.|[5]Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28 (1) :1-6.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-B0471/Phenylephrine-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B0471/Phenylephrine-hydrochloride-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

α adrenergic receptor

Citation 01

BioRxiv. 2025 Jul 30.|bioRxiv. 2025 Jun 27:2025.06.24.660441.|Elife. 2024 May 29.|Free Radic Biol Med. 2024 Feb 20:212:477-492.|Front Cardiovasc Med. 2021 Jun 16:8:679240.|J Cell Mol Med. 2025 Mar;29 (5) :e70488.|J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15:1092:220-227.|Mater Des. 2025 Aug.|Biochem Biophys Res Commun. 2024 Nov 26:735:150844.|Biochem Pharmacol. 2025 Aug 8;242 (Pt 1) :117218.|Biochem Pharmacol. 2025 Oct:240:117107.|Biochim Biophys Acta Mol Basis Dis. 2024 Aug 30:167488.|Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870 (1) :166859.|BMC Cardiovasc Disord. 2025 Jan 6;25 (1) :7.|BMC Pulm Med. 2021 Jun 5;21 (1) :189.|Cell Signal. 2026 Feb:138:112275.|Clin Exp Pharmacol Physiol. 2025 Nov;52 (11) :e70081.|Eur J Pharmacol. 2025 Feb 1:177346.|FASEB J. 2025 May 31;39 (10) :e70670.|Free Radic Biol Med. 2025 Jun 7:237:300-311.|Front Med. 2024 Jun;18 (3) :484-498.|Int Endod J. 2025 Jul 14.|J Adv Res. 2025 Oct 29:S2090-1232 (25) 00848-3.|J Cardiovasc Pharmacol. 2022 Sep 1;80 (3) :430-441.|J Endod. 2023 Dec;49 (12) :1641-1651.e6.|J Ethnopharmacol. 2024 Aug 22:118707.|Mol Med Rep. 2021 Sep;24 (3) :636.|Nat Commun. 2024 Jul 16;15 (1) :5985.|Phytother Res. 2025 May 26.|Sci Rep. 2023 Oct 2;13 (1) :16550.|Sci Rep. 2025 Apr 11;15 (1) :12511.|Trends Biotechnol. 2025 Apr;43 (4) :918-945.

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