Phenylephrine (hydrochloride)
Product Specifications
UNSPSC Description
(R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
Target Antigen
Adrenergic Receptor; Endogenous Metabolite
Type
Reference compound
Related Pathways
GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/_r_-_-_-phenylephrine-hydrochloride.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
OC1=CC([C@@H](O)CNC)=CC=C1.Cl
Molecular Weight
203.67
References & Citations
[1]Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.|[2]Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.|[3]Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13.|[4]Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65.|[5]Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.Elife. 2024 May 29.|Free Radic Biol Med. 2024 Jan 6:S0891-5849(24)00007-8.|Front Cardiovasc Med. 2021 Jun 16;8:679240.|J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:220-227.|Biochem Biophys Res Commun. 2024 Oct 17:735:150844.|Biochim Biophys Acta Mol Basis Dis. 2023 Aug 27;166859.|Biochim Biophys Acta Mol Basis Dis. 2024 Aug 30:167488.|BMC Pulm Med. 2021 Jun 5;21(1):189.|Front Med. 2024 May 14.|J Cardiovasc Pharmacol. 2022 Sep 1;80(3):430-441.|J Endod. 2023 Sep 26:S0099-2399(23)00608-8.|J Ethnopharmacol. 2024 Aug 22:118707.|Mol Med Rep. July 6, 2021.|Nat Commun. 2024 Jul 16;15(1):5985.|Sci Rep. 2023 Oct 2;13(1):16550.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0471/Phenylephrine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0471/Phenylephrine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
61-76-7
Available Sizes
Curated Selection
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