AF3485
AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.
Product Specifications
CAS Number
1195786-61-8
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/af3485.html
Smiles
OCCN(C1=C2C=C(C=C1)NC(C3=CC=CC=C3C(F)(F)F)=O)C4=C2C=CC=C4
Molecular Formula
C22H17F3N2O2
Molecular Weight
398.38
References & Citations
[1]Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
EAKT1-100 100 Tests
EnzyFluo™ Human/Mouse AKT1 (S473) Phosphorylation ELISA Kit
Sign In for Pricing
View Details 
