ABT-510 (acetate)

ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 acetate also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 acetate can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD) [1][2].

Product Specifications

CAS Number

[442526-87-6]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Peptides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/abt-510-acetate.html

Purity

99.61

Solubility

10 mM in DMSO

Smiles

N=C(N)NCCC[C@@H](C(N1CCC[C@H]1C(NCC)=O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC)NC([C@H]([C@H](O)C)NC([C@@H]([C@@H](C)CC)NC([C@H](C(C)C)NC(CNC(CN(C(C)=O)C)=O)=O)=O)=O)=O)=O)=O.CC(O)=O

Molecular Formula

C48H87N13O13

Molecular Weight

1054.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Greenaway J, et.al. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan;8 (1) :64-74. |[2]Punekar S, et.al. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008;75 (1) :9-21. |[3]Isenberg JS, et.al. Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells. Biochem Pharmacol. 2008 Feb 15;75 (4) :875-82.