4-Methylsalicylic acid

4-Methylsalicylic acid is a methyl derivative of Salicylic acid (HY-B0167) . 4-Methylsalicylic acid derivatives inhibit the activity of alkaline phosphatases such as TNAP and IAP. 4-Methylsalicylic acid derivatives exhibit immunosuppressive activity[1][2].

Product Specifications

CAS Number

[50-85-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative; Drug Intermediate

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-methylsalicylic-acid.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC1=CC=C(C(O)=O)C(O)=C1

Molecular Formula

C8H8O3

Molecular Weight

152.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Mumtaz A, et al. Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) : Synthesis and molecular docking studies. Bioorg Chem. 2020 Aug;101:103996.|[2]Yan R, et al. Synthesis, biological evaluation and molecular modeling studies of Schiff bases derived from 4-methylsalicylic acid as potential immunosuppressive agents. Medicinal Chemistry Research, 2013, 22 (12) : 5707-5716.