Propargyl-PEG4-acid
Product Specifications
UNSPSC Description
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/propargyl-peg4-acid.html
Purity
97.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C#CCOCCOCCOCCOCCC(O)=O
Molecular Weight
260.28
References & Citations
[1]Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130481/Propargyl-PEG4-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130481/Propargyl-PEG4-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1415800-32-6
Available Sizes
Curated Selection
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