PF-06305591 (dihydrate)

PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1].

Product Specifications

CAS Number

[2703582-76-5]

Product Name Alternative

(-)-Pindolol; (S)-(-)-Pindolol; S-Pindolol

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-06305591-dihydrate.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)(C)C1=CC=C(NC([C@H]([C@@H](C)C(N)=O)N)=N2)C2=C1.[H]O[H].[H]O[H]

Molecular Formula

C15H26N4O3

Molecular Weight

310.39

References & Citations

[1]Brown AD, et al. The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain. Bioorg Med Chem. 2019 Jan 1;27 (1) :230-239.