Atrasentan (hydrochloride)
Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC50 of 0.0551 nM for ETA[1].
Product Specifications
CAS Number
195733-43-8
Product Name Alternative
ABT-627 (hydrochloride) ; (+) -A 127722 (hydrochloride) ; A-147627 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Atrasentan-hydrochloride.html
Purity
99.82
Solubility
0.1 M HCl : < 1 mg/mL (ultrasonic; warming; adjust pH to 1 with HCl; heat to 60°C) |DMSO : 28.57 mg/mL (ultrasonic) |H2O : 0.5 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)
Smiles
O=C([C@H]1[C@H](C2=CC=C(OC)C=C2)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C3=CC=C(OCO4)C4=C3)O.Cl
Molecular Formula
C29H39ClN2O6
Molecular Weight
547.08
Precautions
H302, H315, H319, H335
References & Citations
[1]Yuyama H, et al. Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. Eur J Pharmacol. 2004 Sep 13;498 (1-3) :171-7.|[2]Banerjee S, et al. In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 combination in prostate cancer. Cancer Res. 2007 Apr 15;67 (8) :3818-26.|[3]Weiss J, et al. Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro. Cancer Chemother Pharmacol. 2011 Oct;68 (4) :1093-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Department Veterinary Clinical Medicine. University of Illinois. 2015.|J Vet Intern Med. 2015 Nov;29 (6) :1584-94.|Mol Immunol. 2019 Oct:114:10-18.|Commun Biol. 2022 Jul 28;5 (1) :750.|Eur J Pharmacol. 2019 Jun 5:852:142-150.|J Cell Mol Med. 2025 Apr;29 (8) :e70547.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC050391-100 1x 100 µL
CD81 / TAPA-1 (1.3.3.22), CF405M conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940177-500 1x 500 µL
CD50 (ICAM-3) (101-1D2), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680017-100 1x 100 µL
Ep-CAM / CD326 (VU-1D9), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040003-500 1x 500 µL
CD45RO (UCHL-1), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680525-100 1x 100 µL
CD63 (MX-49.129.5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details