CCF642
Product Specifications
UNSPSC Description
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity[1].
Target Antigen
Apoptosis; PDI
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCF642.html
Purity
98.0
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C/C3=CC=C([N+]([O-])=O)S3)=S
Molecular Weight
378.45
References & Citations
[1]Vatolin S et al. Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.
Cancer Res. 2016 Jun 1;76(11):3340-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100430/CCF642-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100430/CCF642-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
346640-08-2
Available Sizes
Curated Selection
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