CCF642
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity[1].
Product Specifications
CAS Number
[346640-08-2]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; PDI
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCF642.html
Purity
98.0
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C/C3=CC=C([N+]([O-])=O)S3)=S
Molecular Formula
C15H10N2O4S3
Molecular Weight
378.45
Precautions
H302
References & Citations
[1]Vatolin S et al. Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.
 Cancer Res. 2016 Jun 1;76 (11) :3340-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
36-3632-20 20 µg
Anti-CD59 / Complement Regulatory Protein / Protectin Monoclonal Antibody (Clone: MACIF/2867R)
Ask
View Details 