JTE-952
Product Specifications
UNSPSC Description
JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].
Target Antigen
c-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/JTE-952.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[C@@H](O)CO)=C5
Molecular Weight
518.60
References & Citations
[1]Ikegashira K, et al. Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122906/JTE-952-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122906/JTE-952-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1255303-54-8
Available Sizes
Curated Selection
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