Cyclo (L-Phe-L-Val)
Cyclo (L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL) . cyclo (L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions[1].
Product Specifications
CAS Number
[35590-86-4]
UNSPSC
12352209
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyclo-l-phe-l-val.html
Purity
99.88
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 70°C)
Smiles
O=C(N[C@H]1CC2=CC=CC=C2)[C@@H](NC1=O)C(C)C
Molecular Formula
C14H18N2O2
Molecular Weight
246.30
References & Citations
[1]Kim H, et al. Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans. Molecules. 2019 Jun 4;24 (11) :2111.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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