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Cyclo (L-Phe-L-Val)

Cyclo (L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL) . cyclo (L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions[1].

Product Specifications

CAS Number

35590-86-4

UNSPSC

12352209

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cyclo-l-phe-l-val.html

Purity

99.88

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 70°C)

Smiles

O=C(N[C@H]1CC2=CC=CC=C2)[C@@H](NC1=O)C(C)C

Molecular Formula

C14H18N2O2

Molecular Weight

246.30

References & Citations

[1]Kim H, et al. Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans. Molecules. 2019 Jun 4;24 (11) :2111.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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