Deoxycholic acid-d4
Product Specifications
UNSPSC Description
Deoxycholic acid-d4 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
Target Antigen
Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein;Metabolic Enzyme/Protease;Others
Field of Research
Metabolic Disease
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1C([2H])(C[C@]2([C@@]([H])(C1([2H])[2H])CC[C@@]3([C@@]2(C[C@@H]([C@]4([C@]3(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)O)[H])[H])C)[2H]
Molecular Weight
396.60
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809.|[3]Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information
No Development Reported
CAS Number
112076-61-6
Available Sizes
Curated Selection
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