Deoxycholic acid-d4

Deoxycholic acid-d4 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

Product Specifications

CAS Number

[112076-61-6]

UNSPSC

12352211

Hazard Statement

H225, H301+H311+H331, H370

Target

Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Purity

98.0

Solubility

DMSO : 100mg/mL (ultrasonic)

Smiles

O[C@@H]1C([2H])(C[C@]2([C@@]([H])(C1([2H])[2H])CC[C@@]3([C@@]2(C[C@@H]([C@]4([C@]3(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)O)[H])[H])C)[2H]

Molecular Formula

C24H36D4O4

Molecular Weight

396.60

Precautions

H225, H301+H311+H331, H370

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2 (8) . pii: 91809.|[3]Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6 (4) :788-797.