SM27
SM27 (NSC 37204) is an inhibitor for fibroblast growth factors (FGF) . SM27 inhibits angiogenesis through block of FGF2/HSPGs/FGFR1 complex formation[1].
Product Specifications
CAS Number
[6266-54-2]
Product Name Alternative
NSC 37204
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sm27.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(O)=C2C=C(C=CC2=C1)NC(NC3=CC=C4C=C(C=C(C4=C3)O)S(=O)(O)=O)=O)(O)=O
Molecular Formula
C21H16N2O9S2
Molecular Weight
504.49
References & Citations
[1]Pagano K, et al., Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule. PLoS One. 2012;7 (5) :e36990.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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