SM27

SM27 (NSC 37204) is an inhibitor for fibroblast growth factors (FGF) . SM27 inhibits angiogenesis through block of FGF2/HSPGs/FGFR1 complex formation[1].

Product Specifications

CAS Number

[6266-54-2]

Product Name Alternative

NSC 37204

UNSPSC

12352005

Target

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sm27.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC(O)=C2C=C(C=CC2=C1)NC(NC3=CC=C4C=C(C=C(C4=C3)O)S(=O)(O)=O)=O)(O)=O

Molecular Formula

C21H16N2O9S2

Molecular Weight

504.49

References & Citations

[1]Pagano K, et al., Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule. PLoS One. 2012;7 (5) :e36990.