EPQpYEEIPIYL
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2].
Product Specifications
CAS Number
147612-86-0
UNSPSC
12352209
Target
Src
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/epqpyeeipiyl.html
Purity
99.49
Solubility
H2O : 2 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
O=C(N(CCC1)[C@@H]1C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC(C=C2)=CC=C2O)=O)=O)[C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC3)N3C([C@@H](N)CCC(O)=O)=O)=O)=O)CC(C=C4)=CC=C4O[P](O)(O)=O)=O)=O)=O
Molecular Formula
C66H97N12O24P
Molecular Weight
1473.52
References & Citations
[1]G Payne, et al. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct;1 (2) :99-105.|[2]T D Mulhern, et al. The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure. 1997 Oct 15;5 (10) :1313-23.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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