EPQpYEEIPIYL

EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2].

Product Specifications

CAS Number

[147612-86-0]

UNSPSC

12352209

Target

Src

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/epqpyeeipiyl.html

Purity

99.49

Solubility

H2O : 2 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC(C=C2)=CC=C2O)=O)=O)[C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC3)N3C([C@@H](N)CCC(O)=O)=O)=O)=O)CC(C=C4)=CC=C4O[P](O)(O)=O)=O)=O)=O

Molecular Formula

C66H97N12O24P

Molecular Weight

1473.52

References & Citations

[1]G Payne, et al. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct;1 (2) :99-105.|[2]T D Mulhern, et al. The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure. 1997 Oct 15;5 (10) :1313-23.