Nabumetone-d3

Nabumetone-d3 is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.

Product Specifications

CAS Number

[1216770-08-9]

Product Name Alternative

BRL14777-d3

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology; Cancer

Purity

98.80

Solubility

10 mM in DMSO

Smiles

CC(CCC1=CC2=C(C=C1)C=C(C=C2)OC([2H])([2H])[2H])=O

Molecular Formula

C15H13D3O2

Molecular Weight

231.30

Precautions

H315, H319, H320

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46 (5) :753-6.|[3]Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid) : comparison with indomethacin. Agents Actions. 1992; Spec No:C82-3.