Hydrazine sulfate (99%)

Hydrazine sulfate is an orally active PEPCK inhibitor. Hydrazine sulfate inhibits PEPCK and low-Km ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP+ toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease[1][2][3][4][5][6].

Product Specifications

CAS Number

[10034-93-2]

Product Name Alternative

Diamine sulfate (99%)

UNSPSC

12352200

Hazard Statement

H301, H311, H314, H317, H318, H331, H350, H400, H410

Target

Aldehyde Dehydrogenase (ALDH) ; PEPCK

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hydrazine-sulfate-99.html

Purity

99.32

Solubility

DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NN.OS(=O)(O)=O

Molecular Formula

H6N2O4S

Molecular Weight

130.12

Precautions

H301, H311, H314, H317, H318, H331, H350, H400, H410

References & Citations

[1]Mazzio E, et al. The role of glycolysis and gluconeogenesis in the cytoprotection of neuroblastoma cells against 1-methyl 4-phenylpyridinium ion toxicity. Neurotoxicology. 2003 Jan;24 (1) :137-47. |[2]Chlebowski RT, et al. Hydrazine sulfate influence on nutritional status and survival in non-small-cell lung cancer. J Clin Oncol. 1990 Jan;8 (1) :9-15.|[3]Loprinzi CL, et al. Randomized placebo-controlled evaluation of hydrazine sulfate in patients with advanced colorectal cancer. J Clin Oncol. 1994 Jun;12 (6) :1121-5. |[4]Silverstein R, et al. Modulation of endotoxin lethality in mice by hydrazine sulfate. Infect Immun. 1989 Jul;57 (7) :2072-8. |[5]Silverstein R, et al. Hydrazine sulfate protects D-galactosamine-sensitized mice against endotoxin and tumor necrosis factor/cachectin lethality: evidence of a role for the pituitary. J Exp Med. 1991 Feb 1;173 (2) :357-65.|[6]Suzuki H, et al. Ethanol and hydrazine sulfate induced chronic hepatic injury in rats: the curative effect of administration of glucogenic amino acids. Alcohol Alcohol Suppl. 1993;1A:111-7.