Cobomarsen

Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT) . Cobomarsen can be used for the research of B-cell lymphoma[1][2].

Product Specifications

CAS Number

[1848257-52-2]

Product Name Alternative

MRG-106

UNSPSC

12352208

Target

MicroRNA

Type

Oligonucleotides

Related Pathways

Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cobomarsen.html

Purity

92.58

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Cobomarsen]

Molecular Formula

C148H177N52O77P13S13

Molecular Weight

4736.00

References & Citations

[1]Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183 (3) :428-444.|[2]Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27 (4) :1139-1149.