Anthracene-9-carboxylic acid-d9

Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

Product Specifications

CAS Number

[1219803-78-7]

Product Name Alternative

9-Anthracenecarboxylic acid-d9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Chloride Channel

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Purity

98.94

Solubility

DMSO : 125 mg/mL (ultrasonic; warming)

Smiles

OC(C1=C(C([2H])=C([2H])C([2H])=C2[2H])C2=C([2H])C3=C1C([2H])=C([2H])C([2H])=C3[2H])=O

Molecular Formula

C15HD9O2

Molecular Weight

231.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Cherian OL, Menini A, Boccaccio A. Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel. Biochim Biophys Acta. 2015 Apr;1848 (4) :1005-13.|[3]Piper AS, Greenwood IA. Anomalous effect of anthracene-9-carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells. Br J Pharmacol. 2003 Jan138 (1) :31-8.