Senkirkin

Senkirkin, a pyrrolizidine alkaloid, occured in the aerial parts of the medicinal plant Tussilago farfara, could induce chromosome damage in human lymphocytes. Senkirkin can be metabolized by CYP3A4[1].

Product Specifications

CAS Number

[2318-18-5]

Product Name Alternative

Senkirkine; Renardin

UNSPSC

12352005

Hazard Statement

H300, H341

Target

Cytochrome P450

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/senkirkin.html

Purity

98.79

Solubility

10 mM in DMSO

Smiles

O=C(/C(C[C@@H](C)[C@]1(O)C)=C\C)O[C@](C2=O)([H])CCN(C)C/C=C2/COC1=O

Molecular Formula

C19H27NO6

Molecular Weight

365.42

Precautions

H300, H341

References & Citations

[1]C Kraus, G Abel, et al. [Pyrrolizidine Alkaloids With Chromosome-Damaging Effects on Human Lymphocytes in Vitro]. Planta Med. 1985 Apr; (2) :89-91.|[2]Fashe MM, et al. In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids. Chem Res Toxicol. 2015 Apr 20;28 (4) :702-10.