Loratadine-d4-1

Loratadine-d4-1 (Loratidine-d4-1) is deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators[1].

Product Specifications

CAS Number

[2748435-73-4]

Product Name Alternative

Loratidine-d4-1; SCH 29851-d4-1

UNSPSC

12352005

Target

Dengue Virus; Flavivirus; Histamine Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Infection; Endocrinology; Inflammation/Immunology; Cancer

Smiles

O=C(N1CC([2H])([2H])/C(C([2H])([2H])C1)=C2C3=CC=C(Cl)C=C3CCC4=CC=CN=C4\2)OCC

Molecular Formula

C22H19D4ClN2O2

Molecular Weight

386.91

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Shahen M, et al. Dengue virus causes changes of MicroRNA-genes regulatory network revealing potential targets for antiviral drugs. BMC Syst Biol. 2018 Jan 4;12 (1) :2.|[3]Kleine-Tebbe J, et al. Inhibition of IgE- and non-IgE-mediated histamine release from human basophil leukocytes in vitro by a histamine H1-antagonist, desethoxycarbonyl-loratadine. J Allergy Clin Immunol. 1994;93 (2) :494-500.|[4]Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50.|[5]Menardo JL, Horak F, Danzig MR, Czarlewski W. A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19 (6) :1278-93; discussion 1523-4.|[6]Monroe EW. Loratadine in the treatment of urticaria. Clin Ther. 1997 Mar-Apr;19 (2) :232-42.|[7]Haria M, Fitton A, Peters DH. Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders. Drugs. 1994 Oct;48 (4) :617-37.|[8]Roman IJ, Danzig MR. Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at its use in combination with pseudoephedrine. Clin Rev Allergy. 1993 Spring;11 (1) :89-110.