SMAD5, Mouse (sf9, His-GST)

SMAD5 (dwarfin C, JV5-1, MAD5) is a receptor activated Smad (R-Smad) belonging to the dwarfin/SMAD family. SMAD5 protein is activated by TGF-β receptor type I and binds to SMAD4 to form a trimer active form. SMAD5 is involved in BMP signaling pathway, regulates osteogenesis and is related to embryonic development. SMAD5 can up-regulate Runx2 expression and target osteocalcin and alkaline phosphatase (ALP) to function[1]. SMAD5 Protein, Mouse (sf9, His-GST) has 464 amino acids expressed by sf9 insect cells with N-terminal His- and GST-tag.

[1]Liu B, et al. Smad5: signaling roles in hematopoiesis and osteogenesis. Int J Biochem Cell Biol. 2004 May;36(5):766-70.|[2]Umans L, et al. Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse. Genesis. 2003 Sep;37(1):5-11.