(-) -Menthol

(-) -Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].

Product Specifications

CAS Number

[2216-51-5]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Endogenous Metabolite; TRP Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/_-_-Menthol.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 1.89 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1

Molecular Formula

C10H20O

Molecular Weight

156.27

Precautions

H315, H319

References & Citations

[1]Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D (3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44 (2) :125-30.