(-) -Menthol
(-) -Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].
Product Specifications
CAS Number
2216-51-5
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Endogenous Metabolite; TRP Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_-_-Menthol.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 1.89 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1
Molecular Formula
C10H20O
Molecular Weight
156.27
Precautions
H315, H319
References & Citations
[1]Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D (3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44 (2) :125-30.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
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