Bisnorcymserine
Bisnorcymserine ((-) -Bisnorcymserine) is an inhibitor for butyrylcholinesterase (BChE) with an IC50 of 0.228 nM. Bisnorcymserine reduces the levels of amyloid-β peptide (Aβ), exhibits ameliorates the Alzheimer’s Disease in elderly rat models. Bisnorcymserine is blood-brain barrier penetrate[1].
Product Specifications
CAS Number
219920-81-7
Product Name Alternative
N1, N8-Bisnorcymserine; (-) -Bisnorcymserine
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bisnorcymserine.html
Smiles
O=C(NC1=CC=C(C=C1)C(C)C)OC2=CC3=C(C=C2)N[C@@]4([C@]3(CCN4)C)[H]
Molecular Formula
C21H25N3O2
Molecular Weight
351.44
References & Citations
[1]Kamal MA, et al., Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine. J Alzheimers Dis. 2006 Sep;10 (1) :43-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE
Frequently Asked Questions
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